Many congratulations to Dr. Anita Govers who successfully defended her thesis "Epigenetic regulation of normal and aberrant myelopoiesis: a balancing act". It has been a long journey and super happy that we could celebrate this milestone together with co-promoter Dr. Marije Bartels. Many thanks to the thesis committee Prof. Marry van den Heuval-Eibrink, Prof. Femke van Wijk, Prof. Jurgen Kuball, Prof. Roland Kuiper, Prof. Joop Jansen en Dr. Marc Bierings.
In the last two decades, epigenetic changes have become more and more evident as a contributing factor in aberrant myelopoiesis, however the exact roles are yet poorly understood. Furthermore, knowledge about epigenetic regulation of normal hematopoiesis is far from complete. Nonetheless, the use of chromatin modifying drugs such as HDACi, has rapidly increased in the past years.
Work in this thesis is aimed to increase understanding the effects of epigenetic regulation and epigenetic modifiers on both normal and aberrant hematopoiesis.